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基本資料
姓名: 林秀美
系所: 國立海洋大學 / 生科系大學部課程 [數位教學紀錄]
研究領域: 智慧型藥物遞送系統
辦公(研究)室: 綜合二館302b-2(辦公室)302b-3(研究室)
自我介紹

主要研究領域

有機化學、無機化學、分析化學、奈米技術


相關研究領域

生醫材料、藥物釋放、光學材料、綠色材料


使用生物材料

細胞、海藻、小鼠、斑馬魚


研究計畫簡介

1. 智慧型藥物傳遞系統:中孔洞二氧化矽奈米粒子,藉由材料表面的官能化,賦予標靶、調控釋放功能;摻雜具有光學以及磁性元素使具有可追蹤特性,達到同時具有特定目標控制釋放且可以非侵入式檢測追蹤之多功能智慧型藥物傳遞系統。

2. 多功能骨修復系統:中孔洞二氧化矽生物活性玻璃,材料中含有鈣、磷成份,可作為骨修復之材料;延續上述中孔洞二氧化矽材料本身所具有之優勢,進一步成為具有特定目標藥物治療且可以非侵入式檢測追蹤之多功能可傳遞藥物之骨修復系統。

3. 生物資源/廢棄物轉化之功能性材料:生活周遭常見之物質,如貝殼富含高比例之碳酸鈣、矽藻本身具有的特殊圖案之二氧化矽孔洞結構、稻殼中高含量之二氧化矽,可利用純化的過程,進一步改質成為多功能之再生材料,賦予資源能夠更加有效利用的價值。


實驗室常用技術

中孔洞二氧化矽材料之合成、修飾與鑑定(XRD、BET、TGA、FT-IR、SEM、TEM、SQUID、ICP等)、細胞培養、光譜儀(UV-vis、PL/PLE等)、細胞/動物顯影(Confocal/IVIS)、核磁共振(MRI)等。


未來產業連結

化學工程、奈米材料、藥物載體、綠能技術、生醫材料、光電科技。



歡迎對本實驗室有興趣的你


前來了解與討論


一同加入研究的行列

學校經歷
1. 國立台灣大學 / 化學研究所 (博士)
個人著作
期刊論文
1. Shiow-Yi Chen, Po-Fong Chou, Wai-Kong Chan, and Hsiu-Mei Lin, "Preparation and characterization of mesoporous bioactive glass from agricultural waste rice husk for targeted anticancer drug delivery," Ceramics International, Feb, 2017.
2. Tsung-Yuan Chang, Chih-Min Wang, Tai-Yuan Lin, and Hsiu-Mei Lin, "Conversion of Biowaste Asian Hard Clam (Meretrix lusoria) Shells into White-Emitting Phosphors for Use in Neutral White LEDs," Materials, Dec, 2016.
3. Wang, C. M.; Lee, L. W.; Chang, T. Y.; Fan, B. L.; Wang, C. L., "New 3D Tubular Porous Structure of an Organic–Zincophosphite Framework with Interesting Gas Adsorption and Luminescence Properties," Chemistry-a European Journal, Oct, 2016.
4. Tsung-Yuan Chang,Zhao-Nan Yan, Chun-Chi Wang, Hsing-Chun Li,Hsiu-Mei Lin and Chih-Min Wang, "New hybrid organic-zincophosphate frameworks:single-crystal-to-single-crystal structural transformation and remarkable thermal and chemical stabilities," Dalton Transactions, May, 2016.
5. Chih-Min Wang, Tsung-Yuan Chang, Li-Wei Lee, Hsiu-Mei Lin, Kuang-Lieh Lu and Kwang-Hwa Lii, "The first zinc phosphite with remarkable structural and functional transformations," Chemical Communications, Sep, 2015.
6. Fu-Yin Hsu, Ru-Chun Weng, Hsiu-Mei Lin, Yi-Hsuan Lin, Meng-Ru Lu, Jing-Lun Yu, Hsien-Wen Hsu, "A biomimetic extracellular matrix composed of mesoporous bioactive glass as a bone graft material," Microporous and Mesoporous Materials, Aug, 2015.
7. Yu-Chia Chen, Cih-Su Wang, Tsung-Yuan Chang, Tai-Yuan Lin, Hsiu-Mei Lin and Yang-Fang Chen, "Ultraviolet and visible random lasers assisted by diatom frustules," Optics Express, Jun, 2015.
8. Yu-Chun Chen, Hsiao-Ya Huang, Hsiu-Mei Lin, Fu-Yin Hsu, Yu-Ping Su and Deng-Fwu Hwang, "Biomaterial availability of magnesium substituted beta-tricalcium phosphate converted from sea urchin Tripneustes gratilla shell," Journal of the Ceramic Society of Japan, Jun, 2015.
9. Chiang-Ting Chen, Fang-Chi Hsu, Jeng-Yeh Huang, Chi-Yuan Chang, Tsung-Yuan Chang, Hsiu-Mei Lin, Tai-Yuan Linc and Yang-Fang Chen, "Effects of a thermally stable chlorophyll extract from diatom algae on surface textured Si solar cells," Rsc Advances, Apr, 2015.
10. Fu-Yin Hsu, Meng-Ru Lu, Ru-Chun Weng and Hsiu-Mei Lin, "Hierarchically biomimetic scaffold of a collagen–mesoporous bioactive glass nanofiber," Biomedical Materials, Mar, 2015.
11. Ming-Hsien Chan and Hsiu-Mei Lin, "Preparation and Identification of Multifunctional Mesoporous Silica Nanoparticles for In Vitro and In Vivo Dual-Mode Imaging, Theranostics, and Targeted Tracking," Biomaterials, Jan, 2015.
12. Wang, C. M.; Lee, L. W.; Chang, T. Y.; Chen, Y. C.; Lin, H. M.; Lu, K. L.; Lii, K. H., "Organic-Inorganic Hybrid Zinc Phosphate with 28-Ring Channels," Chemistry-A European Journal, Jan, 2015.
13. Chan, M.-H. and Lin, H.-M., "Preparation and Identification of Multifunctional Mesoporous Silica Nanoparticles for In Vitro and In Vivo Dual-Mode Imaging, Theranostics, and Targeted Tracking," Biomaterials, Impact Factor: 8.312, Dec, 2014.
14. Yu, Y.-H.; Chan, C.-C.; Lai, Y.-C.; Lin, Y.-Y.; Huang, Y.-C.; Chi, W.-F.; Kuo, C.-W.; Lin, H.-M. and Chen, P.-C., "Biocompatible electrospinning poly (vinyl alcohol) nanofibres embedded with graphene-based derivatives with enhanced conductivity, mechanical strength and thermal stability," RSC Advances, Impact Factor: 3.708, 2014.
15. Huang, C.-Y.; Lee, Y.-J.; Lin, T.-Y.; Chang, S.-L.; Lian, J.-T.; Lin, H.-M.; Chen, N.-C. and Yang, Y.-J., "Direct formation of InN-codoped p-ZnO/n-GaN heterojunction diode by solgel spincoating scheme," Optics Letters, Impact Factor: 3.179, 2014.
16. Periasamy, A.-P.; Liu, J.-F.; Lin, H.-M. and Chang, H.-T., "Synthesis of copper nanowire decorated reduced graphene oxide for electro-oxidation of methanol," Journal of Materials Chemistry A, Impact Factor: 6.626, 2013.
17. Lin, H.-M.; Lin, H.-Y. and Chan, M.-H., "Preparation, characterization, and in vitro evaluation of folate-modified mesoporous bioactive glass for targeted anticancer drug carriers," Journal of Materials Chemistry B, Impact Factor: 6.626, 2013.
18. Lin, H.-M.; Lin, Y.-H. and Hsu, F.-Y., "Preparation and characterization of mesoporous bioactive glass/polycaprolactone nanofibrous matrix for bone tissues engineering," Journal of Materials Science-Materials, Impact Factor: 2.141, 2012.
19. Hwang, J.-S.; Kao, M.-C.; Shiu, J.-M.; Fan, C.-N.; Ye, S.-C.; Yu, W.-S.; Lin, H.-M.; Lin, T.-Y.; Chattopadhyay, S.; Chen, L.-C. and Chen, K.-H., "Photocurrent Mapping in High Efficiency Radial P-N Junction Silicon Nanowire Solar Cells Using Atomic Force Microscopy," Journal of Physical Chemistry C, Impact Factor: 4.805, 2011.
20. Lin, H.-M.; Wang, W.-K.; Hsiung, P.-A. and Shyu, S.-G., "Light-sensitive intelligent drug delivery systems of coumarin-modified mesoporous bioactive glass," Acta Biomaterialia, Impact Factor: 4.824, 2010.
21. Chang, J.-R.; Lin, H.-M.; Cheng, S.-W.; Tseng, C.-K.; Tzou D.-L. and Shyu, S.-G., "EXAFS investigation of the morphology of immobilized Rh(PPh3)(3)Cl on phosphinated MCM-41," Journal of Molecular Catalysis A-Chemical, Impact Factor: 2.872, 2010.
22. Lin, R.; Horng, H.-C.; Lin, H.-M.; Lin, S.-Y.; Hon, Y.-S. and Chow, T.-J., "2-Amino-3-naphthylacrylonitrile Derivatives as Green Luminance Dyes," Journal of the Chinese Chemical Society, Impact Factor: 0.718, 2010.
23. Lin, H.-M. and Chang T.-Y., "A 3-D porous metal-organic framework with a bcu topology constructed from 48-membered tetraicosanuclear metallamacrocycle based on in situ ligand synthesis," Crystal Growth & Design, Impact Factor: 4.215, 2009.
專利
1. 林秀美、張宗元、游子毅, "一種以貝殼做為基礎原料所製成之磷酸鈣材料及製造該磷酸鈣材料的方法," 發明第I448419號, 專利期限: 2014-2032