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Name: 鄒文雄
Department: 國立海洋大學 / 生科系大學部課程 [elearning courses]
Research: 計算生物學,生物分子模擬
Office: 綜合二館Rm302A


 分機: 5522 (老師辦公室),  5523 (實驗室)





工具CPU (中央處理器) + GPU (圖形處理器)


膜蛋白SCF-KIT的異位調節(allosteric regulation)

人類血清白蛋白Human Serum Albumin的異位調節(allosteric regulation)





C, Python, Perl, Matlab, R, Gromacs, Amber






1. Jing Hou, Heping Zheng*, Wen‐Shyong Tzou, David R. Cooper, Maksymilian Chruszcz, Mahendra D. Chordia, Keehwan Kwon, Marek Grabowski, Wladek Minor*, "Differences in substrate specificity of V. cholerae FabH enzymes suggest new approaches for the development of novel antibiotics and biofuels.," FEBS J. 2018 Aug;285(15):2900-2921, Aug, 2018.
2. Hung KS, Hsiao CC, Pai TW, Hu CH, Tzou WS, Wang WD, Chen YR, "Functional enrichment analysis based on long noncoding RNA associations.," BMC Syst Biol. 2018 Apr 24;12(Suppl 4):45., Apr, 2018.
3. Pei-Xin Lai, Chung-Wein Chen, Shih-Chun Wei, Tzu-Yu Lin, Hong-Jyuan Jian, Irving Po-Jung Lai, Ju-Yi Mao, Pang-Hung Hsu, Han-Jia Lin, Wen-Shyong Tzou, Shiow-Yi Chen, Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang*, "Ultrastrong Trapping of VEGF by Graphene Oxide: Anti-angiogenesis Application," Biomaterials. 2016 109:12-22., 2016.
4. Chi-Fu Chou, Han-Jia Lin, Chih-Yu Tsai, Tzung-Yi Lin, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li, Tun-Wen Pai, Chin-Hwa Hu, and Wen-Shyong Tzou*., "Hypoxia-inducible factor 2-alpha participates in the regulation of intersegmental vessels angiogenesis and neuromast deposition.," Journal of Marine Science and Technology, Vol. 24, No. 2, pp. 347-358, 2015.
5. Wen‑Sing Liang, Tsuei‑Yun Fang, Hong‑Ting Lin, Tristan C. Liu, Wen‑Jung Lu, Wen‑Shyong Tzou, Shye‑Jye Tang, Fu‑Pang Lin, Shiu‑Mei Liu, Chorng‑Liang Pan*, "Cloning, expression, and characterization of Pseudomonas vesicularis MA103 β‑1,3‑xylanase in Escherichia coli ClearColi BL21(DE3)," Fish Sci (2015) 81:1135–1143, 2015.
6. Wen-Shyong Tzou*, Ying-Tsang Lo, Tun-Wen Pai, Chin-Hwa Hu, Chung-Hao Li., "Stochastic Simulation of Notch Signaling Reveals Novel Factors that Mediate the Differentiation of Neural Stem Cells," Journal of Computational Biology, 21(7):1-20., 2014.
7. Wen-Shyong Tzou*, Ying Chu, Tzung-Yi Lin, Chin-Hwa Hu, Tun-Wen Pai, Hsin-Fu Liu, Han-Jia Lin, Ildeofonso Cases, Ana Rojas, Mayka Sanchez, Zong-Ye You, Ming-Wei Hsu., "Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom.," PLoS One, 9(1): e86718, 2014., 2014.
8. Xing-Guang Hung, Wen-Chi Tseng, Shiu-Mei Liu, Wen-Shyong Tzou, Tsuei-Yun Fang*, "Characterization of a thermophilic l-arabinose isomerase from Characterization of a thermophilic l-arabinose isomerase from thermoanaerobacterium saccharolyticum NTOU1.," Biochemical Engineering Journal, 83:121–128, 2014.
9. Tzung-Yi Lin, Chi-Fu Chou, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li,Jen-Leih Wu, Han-Jia Lin, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou*, "Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo.," PLoS One, 9(7): e101980, 2014.
10. Chien-Ming Chen, Yu-Lun Lu, Chi-Pong Sio, Guan-Chung Wu, Wen-Shyong Tzou, Tun-Wen Pai*, "Gene Ontology based housekeeping gene selection for RNA-seq normalization," Methods, 67(3): 354-363, 2014.
11. Chien-Ming Chen, Tun-Wen Pai*, Chia-Sheng Chuang, Jhen-Li Huang, Wen-Shyong Tzou, Chin-Hua Hu, "Identifying significant associations of orthologous simple sequence repeats with gene ontologies," International Journal of Data Mining and Bioinformatics, 9(1):37-51, 2014.
12. C.-T. Chang, H.-Y. Chung, H.-T. Su, H.-P. Tseng, W.-S. Tzou, C.-H. Hu*., "Regulation of zebrafish CYP3A65 transcription by AHR2," Toxicology and Applied Pharmacology, 270(2):174-184, 2013.
13. H.-Y. Chung, C.-T. Chang, H.-W. Young, S. P. Hu, W.-S. Tzou, C.-H. Hu*., "Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway," Neurotoxicology and Teratology, 38:92-103, 2013.
14. Ying-Tsang Lo, Hsin-Wei Wang, Tun-Wen Pai*, Wen-Shoung Tzou, Hui-Huang Hsu, Hao-Teng Chang., "Protein-ligand binding region prediction (PLB-SAVE) based on geometric features and CUDA acceleration," BMC Bioinformatics, 14 Suppl 4:S4, 2013.
15. Wei-Hung Chang, Chi-Ying Lee, Chih-Yu Lin, Wei-Yun Chen, Meng-Chieh Chen, Wen-Shyong Tzou, and Yet-Ran Chen*., "UniQua: A Universal Signal Processor for MS-Based Qualitative and Quantitative Proteomics Applications," Analytical Chemistry, 85(2):890-897, 2013.
16. Fu-Pang Lin*, Hsiu-Yen Ma, Hui-Ju Lin, Shiu-Mei Liu, Wen-Shyong Tzou, "Biochemical characterization of two truncated forms of amylopullulanase from Thermoanaerobacterium saccharolyticum NTOU1 to identify its enzymatically active region," Applied Biochemistry and Biotechnology, 165(3-4):1047-1056, 2011.
17. C.-S. Chuang, T.-W. Pai*, H.-C. Hu, W.-S. Tzou, M.-D.-T. Chang, H.-T. Chang, C.-C. Chen, "Functional pathway mapping analysis for hypoxia-inducible factors," BMC Systems Biology, 5 Suppl 1:S3, 2011.
18. C.-Y. Ko, M.-Y. Tsai, W.-F. Tseng, C.-H. Cheng, C.-R. Huang, J.-S. Wu, H.-Y. Chung, C.-S. Hsieh, C.-K. Sun, S.-P. Hwang, C.-H. Yuh, C.-J. Huang, T.-W. Pai, W.-S. Tzou and C.-H. Hu*., "Integration of CNS survival and differentiation by HIF2α," Cell Death and Differentiation, 18(11):1757–1770, 2011.
19. K.-S. Hung, S.-M. Liu, T.-Y. Fang, W.-S. Tzou, F.-P. Lin, K.-H. Sun and S.-J. Tang*., "Characterization of a salt-tolerant xylanase from Thermoanaerobacterium saccharolyticum NTOU1," Biotechnology Letters, 33(7):1441-1447, 2011.
20. W.-P. Lee and W.-S. Tzou*., "Fast Revelation of the Motif Mode for a Yeast Protein Interaction Network Through Intelligent Agent-Based Distributed Computing," Protein and Peptide Letters, 17(9):1091-1101, 2010.
21. C.-J. Lin, W.-C. Tseng, T.-H. Lin, S.-M. Liu, W.-S. Tzou and T.-Y. Fang*., "Characterization of a Thermophilic l-Rhamnose Isomerase from Thermoanaerobacterium saccharolyticum NTOU1," Journal of Agricultural and Food Chemistry, 58(19):10431–10436, 2010.
22. C.-M. Chen, C.-C. Chen, T.-H. Shih, T.-W. Pai*, H.-C. Hu, and W.-S. Tzou., "Efficient algorithms for identifying orthologous simple sequence repeats of disease genes," Journal of Systems Science and Complexity, 23:906-916, 2010.
23. W.-S. Tzou, W.-P. Lee* and B.-C. Jeng., "Exploiting knowledge ontology and software agents for PPI network analysis," Expert Systems with Applications, 36(10):12605–12612, 2009.
24. W.-P. Lee and W.-S. Tzou*., "Computational methods for discovering gene networks from expression data," Briefings in Bioinformatics, 10(4):408-423, 2009.
25. Tun-Wen Pai*, Chien-Ming Chen, Meng-Chang Hsiao, Ronshan Cheng, Wen-Shyong Tzou, Chin-Hua Hu., "An online conserved SSR discovery through cross-species comparison," Advances and Applications in Bioinformatics and Chemistry, 2:23-35, 2009.
26. Yin HC, Tseng HP, Chung HY, Ko CY, Tzou WS, Buhler DR, Hu CH*, "Influence of TCDD on zebrafish CYP1B1 transcription during development.," Toxicol Sci. 2008 May;103(1):158-68., 2008.
27. Pai TW*, Chang MD, Tzou WS, Su BH, Wu PC, Chang HT, Chou WI., "REMUS: a tool for identification of unique peptide segments as epitopes.," Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W198-201., 2006.
28. Chuang KH, Cheng CM, Roffler SR, Lu YL, Lin SR, Wang JY, Tzou WS, Su YC, Chen BM, Cheng TL*, "Combination cancer therapy by hapten-targeted prodrug-activating enzymes and cytokines.," Bioconjug Chem. 2006 May-Jun;17(3):707-14., 2006.
29. Lee WP, Jeng BC, Pai TW, Tsai CP, Yu CY, Tzou WS*, "Differential evolutionary conservation of motif modes in the yeast protein interaction network.," BMC Genomics. 2006 Apr 25;7:89., 2006.
30. Wang JY, Yeh CS, Tzou WS, Hsieh JS, Chen FM, Lu CY, Yu FJ, Cheng TL, Huang TJ, Lin SR*, "Analysis of progressively overexpressed genes in tumorigenesis of colorectal cancers using cDNA microarray.," Oncol Rep. 2005 Jul;14(1):65-72., 2005.
31. Howng SL, Sy WD, Cheng TS, Lieu AS, Wang C, Tzou WS, Cho CL, Hong YR., "Genomic organization, alternative splicing, and promoter analysis of human dynamin-like protein gene.," Biochem Biophys Res Commun. 2004 Feb 13;314(3):766-72., 2004.
32. Wang JY, Hsieh JS, Chang MY, Huang TJ, Chen FM, Cheng TL, Alexandersen K, Huang YS, Tzou WS, Lin SR*, "Molecular detection of APC, K- ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers.," World J Surg. 2004 Jul;28(7):721-6., 2004.
33. Wang JY, Hsieh JS, Chen CC, Tzou WS, Cheng TL, Chen FM, Huang TJ, Huang YS, Huang SY, Yang T, Lin SR., "Alterations of APC, c-met, and p53 genes in tumor tissue and serum of patients with gastric cancers.," J Surg Res. 2004 Aug;120(2):242-8., 2004.
34. Yeh CS, Chen FM, Wang JY, Cheng TL, Hwang MJ, Tzou WS*, "Directional shape complementarity at the protein-DNA interface.," J Mol Recognit. 2003 Jul-Aug;16(4):213-22., 2003.
35. Yang PK, Tzou WS, Hwang MJ*, "Restraint-driven formation of alpha-helical coiled coils in molecular dynamics simulations.," Biopolymers. 1999 Nov;50(6):667-77., 1999.
36. Tzou WS, Hwang MJ*, "Modeling helix-turn-helix protein-induced DNA bending with knowledge-based distance restraints.," Biophys J. 1999 Sep;77(3):1191-205., 1999.
37. Lee CY, Yang PK, Tzou WS, Hwang MJ*, "Estimates of relative binding free energies for HIV protease inhibitors using different levels of approximations.," Protein Eng. 1998 Jun;11(6):429-37., 1998.
38. Tzou WS, Hwang MJ*, "A model for Fis N-terminus and Fis-invertase recognition.," FEBS Lett. 1997 Jan 13;401(1):1-5., 1997.
39. Yu SM*, Tzou WS, Lo WS, Kuo YH, Lee HT, Wu R., "Regulation of alpha-amylase-encoding gene expression in germinating seeds and cultured cells of rice.," Gene. 1992 Dec 15;122(2):247-53., 1992.